Publications

2007-2017 - For a full list of publications, inluding new ones that may not have been added yet, please see Dr. Tung's profile on Google Scholar

Ong, C.S., Fukunishi, T., Nashed, A., Blazeski, A., Zhang, H., Hardy, S., DiSilvestre, D., Vricella, L., Conte, J., Tung, L., Tomaselli, G., and Hibino, N. Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting. J. Vis. Exp., e55438, 2017. Abstract.

Morrissette‐McAlmon, J., Blazeski, A., Somers, S., Kostecki, G., Tung, L., and Grayson, W.L. Adipose‐derived perivascular mesenchymal stromal/stem cells promote functional vascular tissue engineering for cardiac regenerative purposes. Journal of tissue engineering and regenerative medicine, 2017. Abstract.

Oh, Y., Cho, G-S., Li, Z., Hong, I., Zhu, R., Kim, M.J., Kim, Y.J., Tampakakis, E., Tung, L., Huganir, R., Dong, X., Kwon, C., and Lee, G. Functional coupling with cardiac muscle promotes maturation of hPSC-derived sympathetic neurons. Cell stem cell 19:95-106. Abstract.

Hunter, D.W., Tandri, H., Halperin, H., Tung, L., and Berger, R.D. Tetanizing prepulse: A novel strategy to mitigate implantable cardioverter-defibrillator shock-related pain. Heart Rhythm 13:1142-1148. Abstract.

Molitoris, J.M., Paliwal, S., Sekar, R.B., Blake, R., Park, JS., Trayanova, N.A., Tung, L., and Levchenko, A. Precisely parameterized experimental and computational models of tissue organization. Integrative Biology 8:230-242, 2016. Abstract.

Zhu, R., Millrod, M. A., Zambidis, E. T. and Tung, L. Variability of action potentials within and among cardiac cell clusters derived from human embryonic stem cells. Sci Rep 6, 18544, 2016. Abstract.

Blazeski, A., Kostecki, G., and Tung, L. Engineered heart slices for electrophysiological and contractile studies. Biomaterials 55:119-128, 2015. Abstract.

Zhu, R., Blazeski, A., Poon, E., Kosta, K. D., Tung, L. and Boheler, K. R. Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther 5:117, 2014. Abstract.

Park, S. A., Lee, S.-R., Tung, L., and Yue, D. T. Optical mapping of optogenetically shaped cardiac action potentials. Sci Rep 4:6125, 2014. Abstract.

Aiba, T., Farinelli, F., Kostecki, G., Hesketh, G. G., Edwards, D., Biswas, S., Tung, L., and Tomaselli, G. F. A mutation causing Brugada Syndrome identifies a mechanism for alered autonomic and oxidant reduction of cardiac sodium currents. Circ Cardiovasc Genet 7:249-256, 2014. Abstract.

Gorospe, G., Zhu, R., Millrod, M. A., Zambidis, E. T., Tung, L. and Vidal, R. Automated grouping of action potentials of human embryonic stem cell-derived cardiomyocytes. IEEE Trans Biomed Eng 61:2389-2395, 2014.

Thompson, S. A., Blazeski, A., Copeland, C. R., Cohen, D. M., Chen, C. S., Reich, D. M., and Tung, L. Acute slowing of cardiac conduction in response to myofibroblast coupling to cardiomyocytes through N-cadherin. J Mol Cell Cardiol 68:29-37, 2014. Abstract.

Joshi-Mukherjee, R., Dick, I. E., Liu, T., O'Rourke, B., Yue, D.T., and Tung, L. Structural and functional plasticity in long-term cultures of adult ventricular myocytes. J Mol Cell Cardiol 65:76-87, 2013. Abstract.

Weinberg, S. H., Chang, K. C., Zhu, R., Tandri, H., Berger, R. D., Trayanova, N. A., and Tung, L. Defibrillation success with high frequency electric fields is related to degree and location of conduction block. Heart Rhythm 10:740-748, 2013. Abstract.

Blazeski, A., Zhu, R., Hunter, D. W., Weinberg, S. H., Boheler, K. R., Zambidis, E. T., and Tung, L. Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells. Prog Biophys Mol Biol 110:178-195, 2012. Abstract.

Blazeski, A., Zhu, R., Hunter, D. W., Weinberg, S. H., Zambidis, E. T., and Tung, L. Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility. Prog Biophys Mol Biol 110:166-177, 2012. Abstract.

Thompson, S. A., Burridge, P. W., Lipke, E. A., Shamblott, M., Zambidis, E. T., and Tung, L. Engraftment of human embryonic stem cell derived cardiomyocytes improves conduction in an arrhythmogenic in vitro model. J Mol Cell Cardiol 53:15-23, 2012. Abstract.

Weinberg, S. H. and Tung, L. Oscillation in cycle length induces transient discordant and steady-state concordant alternans in the heart. PLoS One 7:e40477, 2012. Abstract.

Tandri, H., Weinberg, S.H., Chang, K.C., Zhu, R., Trayanova, N. A., Tung, L. and Berger, R. D. Reversible cardiac conduction block and defibrillation with high-frequency electric field. Sci Trans Med 3:102ra96, 2011. Abstract.

Thompson, S. A., Copeland, C. R., Reich, D. H. and Tung, L. Mechanical coupling between fibroblasts and cardiomyocytes slows electrical conduction in fibrotic cell monolayers. Circ 123:2083-2093, 2011. Abstract.

Burridge, P. W., Thompson, S., Millrod, M. A., Weinberg, S., Yuan, X., Peters, A., Mahairaki, V., Koliatsos, V. E., Tung. L., and Zambidis, E. T. A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability.PLoS ONE 6:e18293, 2011. Abstract.

Tung, L. Expanding on forty years of reflection. J Physiol 589:2107-8, 2011. Abstract.

Tung, L. and Thompson, S. A. Advantages and pitfalls of cell cultures as model systems to study cardiac mechanoelectric coupling. In: Cardiac Mechano-Electric Coupling and Arrhythmias (2nd Ed), P. Kohl, F. Sachs and M. R. Franz, eds, Oxford University Press, Oxford, UK. Chap. 20, 2011.

Limpitikul, W., Christoforou, N., Thompson, S.A., Gearhart, J. D., Tung, L. and Lipke, E. A. Influence of electromechanical activity on cardiac differentiation of mouse embryonic stem cells. Cardiovasc Eng Tech 1:179, 2010.

Weinberg, S., Malhotra, N. and Tung, L. Vulnerable windows define susceptibility to alternans and spatial discordance. Am J Physiol 298:H1727-37, 2010. Abstract.

Kim, D.-H., Lipke, E. A., Kim, P., Cheong, R., Thompson, S., Delannoy, M., Suh, K.-Y., Tung, L. and Levchenko, A. Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. PNAS 107:565-70, 2010. Abstract.

Chang, M. G., Zhang, Y., Chang, C. Y., Xu, L., Emokpae, R., Tung, L., Marban, E., and Abraham, M. R. Spiral waves and reentry dynamics in an in vitro model of the healed infarct border-zone. Circ Res 105:1062-71, 2009. Abstract.

Jacot, J. G., Raskin, A. J., Omens, J. H., McCulloch, A. D., and Tung, L.. Mechanotransduction in cardiac and stem-cell derived cardiac cells. In: Mechanosensitivity in Cells and Tissues: Mechanosensitivity of the Heart, A. Kamkin and I. Kiseleva, eds., Springer, Chap. 5, 2009.

Weinberg, S., Lipke, E. A., and Tung, L.. In vitro electrophysiological mapping of stem cells. In: Stem Cells for Myocardial Regeneration: Methods and Protocols, Methods in Molecular Biology, Randall J. Lee, ed., Humana Press, Chap. 14, 2009.

Sekar, R. B., Kizana, E., Cho, H. C., Molitoris, J. M., Hesketh, G. G., Eaton, B. P., Marban, E. and Tung, L.. IK1 heterogeneity affects genesis and stability of spiral waves in cardiac myocyte monolayers. Circ Res 104:355-364, 2009. Abstract.

Tung, L. The generalized activating function. In: Cardiac Bioelectric Therapy: Mechanisms and Practical Implications, I. Efimov, M. Kroll and P. Tchou, eds., Springer, Chap. 2.3, 2008.

Parker, K. K., Tan, J., Chen, C. S. and Tung, L.. Myofibrillar architecture in engineered cardiac myocytes. Circ Res 103:340-342, 2008. Abstract.

Weinberg, S., Iravanian, S. and Tung, L.. Representation of collective electrical behavior of cardiac cell sheets. Biophys J 95:1138-1150, 2008. Abstract.

Zhang, Y., Sekar, R. B., McCulloch, A. D. and Tung, L.. Cell cultures a models of cardiac mechanoelectric feedback. Prog Biophys Mol Biol 97:367-382, 2008. Abstract.

Cysyk, J. and Tung, L.. Electric field perturbations of spiral waves attached to millimeter-size obstacles. Biophys J 94:1533-1541, 2008. Abstract.

Lin, J. W., Garber, L., Qi, Y. R., Chang, M. G., Cysyk, J. and Tung, L.. Region of slowed conduction acts as core for spiral wave reentry in cardiac cell monolayers. Am J Physiol Circ Physiol 294:H58-H65, 2008. Abstract.

Tung, L. and Cysyk, J.. Imaging fibrillation/defibrillation in a dish. J Electrocardiol 40:S62-S65, 2007. Abstract.

Bursac, N., Loo, Y., Leong, K. and Tung, L.. Novel anisotropic engineered cardiac tissues: studies of electrical propagation. Biochem Biophys Res Comm 361:847-853, 2007. Abstract.

Sekar, R. B., Kizana, E., Smith, R. R., Barth, A. S., Zhang, Y., Marban, E. and Tung, L.. Lentiviral vector mediated expression of GFP or Kir2.1 alters the electrophysiology of neonatal rat ventricular myocytes without inducing cytotoxicity. Am J Physiol 293:H2757-H2770, 2007. Abstract.

Kizana, E., Chang, C., Cingolani, E., Ramirez-Correa, G. A., Sekar, R. B., Abraham, M. R., Ginn, S. L., Tung, L., Alexander, I. E. and Marban, E.. Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapy.Circ Res 100:1597-604, 2007. Abstract.

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