Recent News:
5/2015: David Hunter presents at the Heart Rhythm Society Meeting in Boston, MA.

4/2015: Yin Wang, M.D.,Ph.D. joins the CBS lab from Huazhong University of Science and Technology.

4/2015: Adriana Blazeski and Geran Kostecki are lead authors of "Engineered heart slices for electrophysiological and contractile studies" in Biomaterials.

3/2015: CBS Lab attends the Gordon Research Conference on Cardiac Arrhythmia Mechanisms in Barga, Italy.

10/2014: Adriana Blazeski and Geran Kostecki present at the BMES annual conference in San Antonio.

10/2014: Renjun Zhu is lead author of "Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes" in Stem Cell Research & Therapy.

9/2014: Venkatesh Hariharan joins the CBS lab from the Cardiac Biomechanics and Mechanotranduction Lab at Columbia University.

6/2014: David Hunter receives an AHA predoctoral fellowship.

3/2014: Susan Thompson is lead author of "Acute slowing of cardiac conduction in response to myofibroblast coupling to cardiomyocytes through N-cadherin" in Journal of Molecular and Cellular Cardiology.





Welcome to the Cardiac Bioelectric Systems Lab

Our research is focused on both the physiological and pathophysiological function of cardiac cells at a multicellular, syncytial level. We use cell culture models in a manner akin to mathematical models in which elements of the model can be designed, synthesized or controlled. 

Our traditional approach consists of cultured, confluent monolayers of cardiac cells that number in the tens of thousands to a million. These cell monolayers can be engineered in terms of their tissue architecture, cell type, protein expression, and microenvironment, can be modelled using computational tools, and have been used to study clinically relevant phenomena in the heart that include electrical stimulation, electrical propagation, arrhythmia and cell therapy. 

In recent years we have expanded the scope of our studies from animal heart cells to human stem cell-derived heart cells (both healthy and patient-derived), and from two-dimensional monolayers to three-dimensional engineered tissues. We are particularly interested in translational applications of our work, and collaborate with other laboratories to develop and test new technologies that may have clinical applications in the diagnosis and treatment of cardiovascular disease.